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A highly convergent approach to O- and N-linked glycopeptide analogues
F Peri1, L Cipolla, B La Ferla
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano.
Glycoconjugate Journal
|March 29, 2000
Abstract:
Deprotected C-glycopyranosyl-ketones have been conjugated by a chemoselective approach to a peptide or an amino acid bearing an aminooxy group on the N-terminus or on the side-chain, respectively. The coupling reaction, performed in aqueous media, does not require protecting groups on the peptide or saccharide moieties, nor auxiliary coupling reagents.