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Hematopoiesis and angiogenesis: a link between two apparently independent processes
D Ribatti1, A Vacca, L Roncali
1Institute of Human Anatomy, Histology, and Embryology, University of Bari Medical School, Italy.
Journal of Hematotherapy & Stem Cell Research
|March 30, 2000
Summary
Hematopoiesis and angiogenesis are linked in early development. Angiogenic factors and hematopoietic cytokines influence each other, supporting the hemangioblast hypothesis for blood and vessel cell origins.
Area of Science:
- Developmental biology
- Hematology
- Vascular biology
Background:
- Hematopoiesis (blood cell formation) and angiogenesis (blood vessel formation) are intricately linked during early embryonic development.
- Previous research suggested a close relationship, but the underlying mechanisms and common origins were debated.
Purpose of the Study:
- To review recent studies investigating the interplay between angiogenic factors and hematopoietic cytokines.
- To evaluate evidence supporting a common progenitor for blood and endothelial cells.
Main Methods:
- Review of current literature on endothelial cell regulation by angiogenic factors.
- Analysis of studies on hematopoietic cytokine effects on endothelial cells.
- Synthesis of findings to assess the hemangioblast hypothesis.
Main Results:
- Angiogenic factors promote hematopoietic cell growth by regulating endothelial cell proliferation and differentiation.
- Hematopoietic cytokines modulate various endothelial cell functions.
- Evidence consistently supports the bidirectional influence between these two systems.
Conclusions:
- The findings strongly support the hemangioblast hypothesis, proposing a shared ancestral cell for both endothelial and hematopoietic lineages.
- This review highlights the critical role of molecular crosstalk in early ontogeny for establishing distinct cell types from a common origin.