Related Experiment Videos
RNA on the road to myelin
E Barbarese1, C Brumwell, S Kwon
1Departments of Neurology, Graduate Programs, University of Connecticut Health Center, Farmington, CT, USA.
Journal of Neurocytology
|March 30, 2000
Abstract:
In oligodendrocytes some mRNAs are transported from the perikaryon to the distal processes and localized in the myelin compartment where they are translated. This review describes the cis-acting signals and trans-acting factors that mediate intracellular trafficking of myelin basic protein (MBP) RNA, the prototype for such mRNAs in myelinating glia.