Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of the Mouth01:26

Assessment of the Mouth

1.6K
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
1.6K
The Oral Microbiota01:27

The Oral Microbiota

90
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
90
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

65
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
65

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral Pain and Alzheimer's Disease: Prospective Cohort and Cross-Sectional Analyses.

Journal of dental research·2026
Same author

Salivary Metal Ions as Potential Biomarkers for Diabetes: An Observational Study.

International journal of dentistry·2026
Same author

Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression.

Nature communications·2025
Same author

Prevention of cancer initiation by augmenting MHC-I antigen presentation via EZH2 inhibition.

Oncogene·2025
Same author

WNT signaling in cancer: molecular mechanisms and potential therapies.

Molecular biomedicine·2025
Same author

Serum amyloid A: multifaceted roles in inflammation and cellular interactions.

Immunologic research·2025

Related Experiment Video

Updated: May 6, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci
11:09

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

18.2K

OralDB: A Transcriptomic Resource for Mechanistic Exploration in Oral Diseases.

H Cui1, Y Lu1, G Zhao1

  • 1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Journal of Dental Research
|March 9, 2026
PubMed
Summary

OralDB is a new resource for oral disease research, integrating diverse transcriptomic data. It aids in understanding complex molecular mechanisms and developing new therapies for oral cancers and periodontitis.

Keywords:
multiomicsoral cancerperiodontitissingle-cell RNA-seqspatial transcriptomicstranscriptomics database

More Related Videos

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

4.3K
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.8K

Related Experiment Videos

Last Updated: May 6, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci
11:09

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

18.2K
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

4.3K
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.8K

Area of Science:

  • Oral biology and disease research
  • Genomics and transcriptomics
  • Computational biology and bioinformatics

Background:

  • Oral diseases like cancer and periodontitis present significant global health challenges.
  • Molecular mechanisms underlying oral diseases are complex and not fully understood.
  • Existing transcriptomic data for oral diseases are fragmented, hindering integrated analysis.

Purpose of the Study:

  • To develop the first comprehensive, standardized, and interactive multimodal transcriptomic resource for oral diseases.
  • To address challenges in integrating fragmented public datasets and overcoming batch effects.
  • To facilitate mechanistic insights and translational applications in oral disease research.

Main Methods:

  • Integrated 73 high-quality datasets across 20 oral diseases and 4 omics types (microarray, RNA-seq, scRNA-seq, ST) from 2,027 samples.
  • Applied rigorous processing pipelines including quality control, dimensionality reduction, clustering, and cell-type annotation.
  • Developed interactive analytical modules for gene expression visualization, differential expression, pathway enrichment, and cell-cell interaction analysis.

Main Results:

  • Launched OralDB (https://compbio.cn/oraldb/), a centralized resource for oral disease transcriptomic data.
  • Demonstrated OralDB's utility in case studies, revealing SERPINE2 in oral cancer EMT and CXCL1 in periodontitis-associated myeloid cell recruitment.
  • Enabled efficient exploration of molecular and cellular features across various oral disease contexts.

Conclusions:

  • OralDB provides a robust platform for advancing precision research in oral diseases.
  • The resource facilitates the discovery of novel therapeutic targets and strategies.
  • OralDB supports the development of innovative treatments for oral cancer, periodontitis, and other oral mucosal disorders.