Related Experiment Video
Updated: Aug 8, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
[The first episode of central nervous system demyelinization and hepatitis B virus vaccination]
E Touzé1, O Gout, M H Verdier-Taillefer
1Unité de Recherches Epidémiologiques en Neurologie et Psychopathologie, INSERM U360, Paris, France. e.touze@wanadoo.fr
Background:
Central nervous system (CNS) demyelinating episodes have been described following numerous vaccines but there is no definite conclusion about a causal relationship. Recently, in France, in the context of an Expanded Program on Immunization, several cases of CNS demyelination have been observed following injection of recombinant hepatitis B (HB) vaccine, leading to great concern.
Methods:
We performed a hospital-based case-control study of 121 patients with a first episode of CNS demyelination occuring between July 1993 and December 1995 and 121 age and sex matched controls seen in the same period. Data on vaccinations history of cases and controls were collected by a postal questionnaire and confirmed by a phone interview.
Results:
Adjusted odds ratio (OR) obtained from conditional logistic regression between a first episode of CNS demyelination and any vaccination were equal to 1.4 (95 p. 100 CI 0. 5-4.3) for an exposure within the 60 previous days and 2.1 (95 p. 100 CI 0.7-6.0) for an exposure within the 61-180 previous days. Similar results were found for HB vaccine exposure within the 60 previous days (adjusted OR=1.7, 95 p. 100 CI 0.5-6.3) or within the 61 to 180 previous days (adjusted OR= 1.5, 95 p. 100 CI 0.5-5.3).
Conclusion:
These findings did not permit to exclude confidently an association between HB vaccine and the occurrence of a first CNS demyelinating episode.
More Related Videos
Related Concept Videos
Viral Meningitis
Poliomyelitis
Hepatitis
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Viral Hepatitis I: Introduction

