[Tissue factor and inhibitor of the blood coagulation pathway in nephrotic syndrome]

Some parameters of extrinsic coagulation pathway, vitronectin and thrombomodulin were studied in 21 patients with nephrotic syndrome. Concentrations of tissue factor and tissue factor pathway inhibitor were found to be significantly elevated in patients with nephrotic syndrome when compared to control group. Activities of tissue factor and tissue factor pathway inhibitor as well as vitronectin did not differ significantly from the healthy volunteers. Activities of factor VII and X were significantly higher in nephrotic patients when compared to the control group. Thrombomodulin--a marker of endothelial cell injury was significantly higher in patients with nephrotic syndrome relative to controls.