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Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

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Related Experiment Video

Updated: Jul 22, 2026

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Relationship between Ras pathways and cell cycle control.

M E Ewen1

  • 1Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Progress in Cell Cycle Research
|March 31, 2000
PubMed
Summary

Cell cycle progression relies on genome duplication and cell division. This review explores how Ras-mediated signals influence the cell cycle

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Signal Transduction

Background:

  • Cell cycle progression involves ordered genome duplication and cell division.
  • Extracellular conditions regulate cell cycling, with a critical control point known as the restriction point.
  • Understanding how external signals affect cell proliferation is crucial.

Purpose of the Study:

  • To review Ras-mediated mitogenic signal transduction pathways.
  • To examine the impact of these pathways on restriction point control.
  • To elucidate the link between extracellular signaling and cell cycle progression.

Main Methods:

  • Literature review of studies on Ras signaling and cell cycle control.
  • Analysis of molecular mechanisms underlying mitogenic signal transduction.

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Analysis of Cell Cycle Position in Mammalian Cells
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  • Integration of findings on restriction point regulation.

    • Main Results:

    • Ras signaling pathways are diverse and significantly impact cell cycle progression.
    • These pathways converge on the restriction point, a key decision-making node.
    • Mitogenic signals mediated by Ras influence the transition from quiescent to proliferative states.

    Conclusions:

    • Ras-mediated signaling is central to controlling cell proliferation by regulating the restriction point.
    • Understanding these pathways provides insights into cell cycle regulation and potential therapeutic targets.
    • Further research into specific Ras pathway components can clarify their roles in cell cycle control.