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2B4 functions as a co-receptor in human NK cell activation

S Sivori1, S Parolini, M Falco

  • 1Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Italy.

European Journal of Immunology
|March 31, 2000
PubMed
Summary

Natural cytotoxicity receptors (NKp46) are crucial for NK cell activation. Human 2B4 triggering depends on NKp46 engagement, not 2B4 molecule heterogeneity, for effective natural cytotoxicity.

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