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Novel peptidomimetic hematoregulatory compounds
D A Heerding1, M Abruzzese, D Alberts
1Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com
Bioorganic & Medicinal Chemistry Letters
|March 31, 2000
Abstract:
The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.