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2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity
C Kunick1, C Schultz, T Lemcke
1Institut für Pharmazie, Abteilung für Pharmazeutische Chemie, Universität Hamburg, Germany. kunick@chemie.uni-hamburg.de
Bioorganic & Medicinal Chemistry Letters
|March 31, 2000
Abstract:
9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synthesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity.