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Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation
C Altomare1, L Summo, S Cellamare
1Dipartimento Farmacochimico, Università degli Studi, Bari, Italy. altomare@farmchim.uniba.it
Bioorganic & Medicinal Chemistry Letters
|March 31, 2000
Abstract:
A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5'-diphosphate (ADP). Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity.