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Published on: March 26, 2018
[Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia]
Objective:
To reveal the incidence of MLL gene rearrangement and its clinical, features in acute myelomonocytic leukemia (M4) and acute monocytic leukemia (M5).
Methods:
10 patients with M4 and 27 cases with M5 were studied with the Southern blot technique to detect MLL gene abnormalities.
Results:
5 M5 patients were found to have MLL rearrangement, and these patients were characterized clinically by: (1) Younger at onset, (2) a higher white blood cell count (often > 100 x 10(9)/L), (3) frequent extramedullary involvement with hepatosplenomegaly and central nervous system leukemia (CNSL), and (4) a lower remission rate with a short survival time.
Conclusion:
There is a high incidence of MLL rearrangement in M5, and this gene abnormality stands for a marker of poor prognosis.