[Quantitative observation of expression of proliferation cell nuclear antigen in nasopharyngeal carcinoma]

Eighty-two cases of nasopharyngeal squamous cell carcinoma and twenty-five cases of nasopharyngitis were studied by means of LAS-SP immunohistochemical method with monoclonal anti-PCNA antibody and using image pattern analysis technique; correlation analysis was performed on expression of PCNA and five-year survival rate. It was shown: 1. The cell proliferative index and pathological grading of NPC were positively correlated, and the cell proliferative index and five-year survival rate negatively correlated. 2. PCNA expression level and pathological grading of NPC were positively correlated, and PCNA expression levels and five years survival rate negatively correlated in all pathological gradings of NPC except the vesicular nucleus cell carcinoma. The results indicate that PCNA affects proliferation activity of NPC and there are bright prospects for their application in the clinic. Expression of PCNA may also become a good indicator of the prognosis of NPC and the choice of treatment.