Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A high-yield microassembly structure for three-dimensional microelectrode arrays.

Q Bai1, K D Wise, D J Anderson

  • 1Advanced Technology Department, Guidant Corporation, St. Paul, MN 55112-5798, USA.

IEEE Transactions on Bio-Medical Engineering
|April 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Actuarial and reproductive senescence in a long-lived seabird: preliminary evidence.

Experimental gerontology·2003
Same author

T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region.

Genes and immunity·2002
Same author

Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations.

Annual review of cell and developmental biology·2001
Same author

The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.

Neuron·2001
Same author

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.

Cell·2001
Same author

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation.

Journal of the Association for Research in Otolaryngology : JARO·2001
Same journal

Highly Accelerated 1-mm Isotropic 3D Chemical Exchange Saturation Transfer MRI Using Wave-Co-CAIPI at 5 Tesla.

IEEE transactions on bio-medical engineering·2026
Same journal

Systematic Evaluation of Hip Exoskeleton Assistance Parameters for Enhancing Gait Stability During Ground Slip Perturbations.

IEEE transactions on bio-medical engineering·2026
Same journal

SleepConFormer: A Single-Channel EEG Framework for Sleep Staging and Consciousness Assessment in Patients with Disorders of Consciousness.

IEEE transactions on bio-medical engineering·2026
Same journal

Modeling Partial and Total Support of Left Ventricular Assist Device for Discrete Hemodynamic Control Framework.

IEEE transactions on bio-medical engineering·2026
Same journal

A Low-Cost Wearable TI-TACS Stimulator With Bipolar Quadratic-Boost Converter for Current Stimulation Validation in the Rat Brain.

IEEE transactions on bio-medical engineering·2026
Same journal

EMG-Based Gait Estimation Using Koopman-Inspired Method.

IEEE transactions on bio-medical engineering·2026
See all related articles

This study introduces a novel microassembly technique for creating 3-D microelectrode arrays for central nervous system (CNS) recording. The method enables rapid, high-density array fabrication and successful neural recordings.

Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Developing high-density microelectrode arrays is crucial for advanced neural recording and stimulation in the central nervous system (CNS).
  • Existing methods face challenges in assembly speed, probe density, and minimizing tissue damage during implantation.

Purpose of the Study:

  • To present a practical microassembly process for fabricating 3-D microelectrode arrays.
  • To demonstrate the capability of these arrays for neural recording and stimulation.
  • To explore an effective implantation technique for high-density arrays.

Main Methods:

  • Utilized wire-free ultrasonic bonding to connect micromachined 2-D probes to a cortical surface platform.
  • Employed low-profile outrigger probe designs for high-density array assembly.

Related Experiment Videos

  • Developed micromachined assembly tools for rapid 3-D array formation (under 30 min).
  • Investigated a dynamic insertion technique for high-speed, low-trauma implantation.

    • Main Results:

    • Successfully fabricated 3-D microelectrode arrays with up to 8x16 shanks on 200-micron centers.
    • Achieved successful recording of cortical single units using the fabricated arrays.
    • Created active 3-D probe arrays with integrated CMOS signal processing circuitry.
    • Demonstrated high-speed implantation into feline cortex with minimal traumatic injury.

    Conclusions:

    • The presented microassembly process offers a practical and efficient method for producing high-density 3-D microelectrode arrays.
    • These arrays are suitable for advanced neural recording and stimulation applications in the CNS.
    • The dynamic insertion technique facilitates minimally invasive implantation of dense neural probes.