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Mutagenic activity of selenium compounds.

M Noda, T Takano, H Sakurai

    Mutation Research
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Selenate and selenite are weak mutagens, causing base-pair substitutions in bacterial tests. These findings are crucial for understanding the genotoxicity of selenium compounds in environmental and biological systems.

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    Area of Science:

    • Environmental Toxicology
    • Genetics and Mutagenesis
    • Inorganic Chemistry

    Background:

    • Selenium compounds, including selenate and selenite, are prevalent in the environment and can enter biological systems.
    • Understanding the potential genotoxic effects of these selenium species is essential for risk assessment.
    • Bacterial mutagenicity assays are standard tools for initial screening of chemical genotoxicity.

    Purpose of the Study:

    • To evaluate the mutagenic potential of selenate and selenite using established bacterial test systems.
    • To characterize the type of genetic mutation induced by these selenium compounds.

    Main Methods:

    • Utilized Kada's rec-assay to assess DNA damage and repair.
    • Employed the Ames Salmonella test for detecting gene mutations.

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  • Quantified mutagenic activity in terms of revertants per nanomole (revertants/nmole).

    • Main Results:

    • Both selenate and selenite demonstrated weak mutagenic activity in both assay systems.
    • In the Salmonella test, selenate induced mutations at a rate of 0.05 revertants/nmole.
    • Selenite showed a higher mutagenic rate of 0.2 revertants/nmole, indicating base-pair substitution mutations.

    Conclusions:

    • Selenate and selenite are confirmed as weak mutagens.
    • The observed mutations are primarily of the base-pair substitution type.
    • These findings contribute to the toxicological profile of selenium compounds.