Free oxygen radicals in acute renal failure

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Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

N K Dubey1, P Yadav, A K Dutta

  • 1Department of Pediatric Intensive Care, Kalawati Saran Children's Hospital and Lady Hardinge Medical College, Bangla Sahib Marg, New Delhi 110 001, India. dubeyn.k@ndfdel.in

Indian Pediatrics
|April 4, 2000
PubMed

Insights

Free oxygen radical markers, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and lipid peroxide (LPO), are elevated in children with acute renal failure. LPO levels show high sensitivity and specificity in predicting clinical outcomes.

Area of Science:

  • Pediatric Nephrology
  • Biochemistry
  • Critical Care Medicine

Background:

  • Acute renal failure (ARF) in children presents significant clinical challenges.
  • Free oxygen radicals (FORs) are implicated in the pathophysiology of various critical illnesses.
  • Understanding FORs' role in pediatric ARF is crucial for predicting outcomes.

Purpose of the Study:

  • To evaluate the levels of FORs in pediatric patients with ARF.
  • To determine the predictive value of FORs for clinical outcomes in ARF.
  • To identify specific FOR markers for renal injury and prognosis.

Main Methods:

  • Prospective study conducted in an intensive care unit setting.
  • Involved 50 children: 25 with ARF and 25 age/sex-matched controls.
  • Measured blood urea, serum creatinine, serum protein, uric acid, and FOR markers (SOD, GPx, LPO).

Main Results:

  • Hemolytic uremic syndrome (HUS) was the primary cause of ARF (52%).
  • Elevated levels of SOD, GPx, and LPO were observed in the ARF group compared to controls.
  • Higher LPO, SOD, and GPx levels correlated with increased mortality.
  • Lipid peroxide (LPO) demonstrated high sensitivity (89.4%) and specificity (93%) in predicting clinical outcome.

Conclusions:

  • FOR levels (SOD, LPO, GPx) are significantly increased in pediatric acute renal failure.
  • These FOR markers can serve as indicators of renal injury.
  • Lipid peroxide (LPO) is a highly sensitive and specific predictor of clinical outcomes in pediatric ARF.
Abstract

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