Related Experiment Videos
Influence of different stent materials on endothelialization in vitro
V Nikolaychik1, H Sahota, M H Keelan
1Medical College of Wisconsin, Department of Cardiovascular Medicine, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
The Journal of Invasive Cardiology
|April 4, 2000
Summary
Gold stents promote better endothelial cell growth compared to stainless steel, potentially reducing complications like hyperplasia and thrombosis after stenting. This research highlights gold
Area of Science:
- Biomaterials Science
- Vascular Biology
- Medical Device Engineering
Background:
- Stent implantation can lead to complications such as neointimal hyperplasia and thrombosis.
- Endothelialization is crucial for the long-term success and biocompatibility of vascular stents.
Purpose of the Study:
- To evaluate the in vitro endothelialization potential of different stent materials.
- To compare the biocompatibility of 316 L stainless steel, 18 K gold, and 24 K gold for vascular stent applications.
Main Methods:
- Utilized the Alamar Blue assay for non-destructive assessment of cell proliferation.
- Employed scanning electron microscopy to analyze vascular cell morphology.
- Cultured human endothelial cells (EC) on disks of stainless steel and gold alloys.
Main Results:
- Significantly higher human EC proliferative capacity was observed on gold surfaces (18 K and 24 K) compared to 316 L stainless steel.
- Gold surfaces supported superior long-term growth and morphology of vascular cells.
- 316 L stainless steel exhibited lower endothelial cell support.
Conclusions:
- Gold alloys demonstrate superior biocompatibility for endothelialization compared to 316 L stainless steel.
- The use of gold stents may mitigate post-stenting complications like hyperplasia and thrombosis.
- Enhanced support for a functional neo-endothelium suggests potential clinical benefits of gold stents.