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ModBase: a database of comparative protein structure models.

R Sánchez1, A Sali

  • 1Pels Family Center for Biochemistry and Structural Biology, Rockefeller University, New York, NY 10021, USA.

Bioinformatics (Oxford, England)
|April 4, 2000
PubMed
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ModBase provides evaluated comparative protein structure models, including fold assignments and alignments. This resource aids researchers in understanding protein structures and their evolutionary relationships.

Area of Science:

  • Structural biology
  • Bioinformatics

Background:

  • Comparative protein modeling is crucial for understanding protein function and evolution.
  • Databases of protein models facilitate structural biology research.

Purpose of the Study:

  • To introduce ModBase, a comprehensive database of evaluated and annotated comparative protein structure models.
  • To provide researchers with access to reliable protein structure models and associated data.

Main Methods:

  • Development of ModBase as a repository for comparative protein models.
  • Inclusion of fold assignments and alignments for each model.
  • Annotation and evaluation of the quality of the protein models.

Main Results:

  • ModBase offers a curated collection of protein structure models.

Related Experiment Videos

  • The database provides fold assignments and alignments, enabling detailed structural analysis.
  • Evaluated models ensure reliability for downstream applications.

    • Conclusions:

    • ModBase serves as a valuable resource for structural biologists and bioinformaticians.
    • The database enhances the accessibility and utility of comparative protein models.
    • ModBase supports research in protein structure, function, and evolution.