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MS functional composite: relation to disease phenotype and disability strata.

N F Kalkers1, V de Groot, R H Lazeron

  • 1Department of Neurology, Academisch Ziekenhuis Vrije Universiteit Amsterdam, The Netherlands. nk.kalkers@azvu.nl

Neurology
|April 4, 2000
PubMed
Summary

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The MS Functional Composite (MSFC) effectively measures multiple sclerosis (MS) patient function across different disease types and disability levels. This study confirms its validity and strong correlation with the Expanded Disability Status Scale (EDSS).

Area of Science:

  • Neurology
  • Clinical Trials
  • Rehabilitation Medicine

Background:

  • The MS Functional Composite (MSFC) is a novel outcome measure for assessing multiple sclerosis (MS) in clinical trials.
  • Its utility across different MS phenotypes and disability strata requires further validation.

Purpose of the Study:

  • To evaluate the MS Functional Composite (MSFC) in various multiple sclerosis (MS) subgroups.
  • To compare the MSFC with the Expanded Disability Status Scale (EDSS) for concurrent validity.

Main Methods:

  • The MSFC was administered to 240 MS patients across relapsing-remitting, primary progressive, and secondary progressive phenotypes.
  • Correlations between MSFC, its components (arm/hand function, leg function/ambulation, cognition), and EDSS were analyzed.
  • An external reference population was used to assess score interpretation.

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Main Results:

  • The MSFC demonstrated varying scores across MS subgroups, being positive in relapsing-remitting and mildly disabled patients, and negative in progressive and more disabled groups.
  • A strong negative correlation (-0.68) was found between EDSS and MSFC.
  • EDSS strongly correlated with ambulation, moderately with arm/hand function, and not with cognition, highlighting MSFC's unique contribution.

Conclusions:

  • The MSFC shows confirmed construct validity and good concurrent validity with the EDSS in diverse MS populations.
  • The MSFC provides valuable insights into cognitive function, complementing the EDSS.
  • This study supports the MSFC as a robust measure for MS clinical trials.