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Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides
I A Kozlov1, M Zielinski, B Allart
1The Salk Institute for Biological Studies, San Diego, California 92186, USA.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 5, 2000
Abstract:
Altritol nucleic acids (ANAs) are RNA analogues with a phosphorylated D-altritol backbone. The nucleobase is attached at the 2-(S)-position of the carbohydrate moiety. We report that ANA oligomers are superior to the corresponding DNA, RNA, and HNA (hexitol nucleic acid) in supporting efficient nonenzymatic template-directed synthesis of complementary RNAs from nucleoside-5'-phosphoro-2-methyl imidazolides. Activated ANA and HNA monomers do not oligomerize efficiently on DNA, RNA, HNA, or ANA templates.