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A temperature-regulated replicon-based DNA expression system.

M Boorsma1, L Nieba, D Koller

  • 1Cytos Biotechnology AG, Wagistrasse 21, CH-8952 Zürich-Schlieren, Switzerland.

Nature Biotechnology
|April 5, 2000
PubMed
Summary

This study introduces a novel temperature-regulated DNA expression system using alphavirus replicons. This system offers high inducibility and low background, simplifying bioprocess engineering for toxic protein expression.

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