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XE-CT CBF changes during normative aging, cognitive decline and dementia.

J S Meyer¹, G M Rauch, R A Rauch

¹Cerebrovascular Research Laboratories, Veterans Administration Medical Center, Houston, TX, USA.

The Keio Journal of Medicine

|April 6, 2000

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Certain lifestyle factors like hypertension and smoking accelerate cognitive decline and dementia. Managing these risks may help preserve brain health and cognitive function.

Area of Science:

Neurology
Gerontology
Public Health

Background:

Cerebral degenerative changes are linked to cognitive decline and dementia.
Identifying modifiable risk factors is crucial for preventative strategies.

Purpose of the Study:

To investigate the correlation between putative risk factors and indicators of cerebral degeneration.
To assess the impact of these factors on cognitive decline and dementia progression.

Main Methods:

Correlational analysis of risk factors with repeated measures of cerebral atrophy, CT densitometry, and perfusions.
Cognitive testing in neurologically and cognitively normative volunteers.

Main Results:

Transient ischemic attacks (TIAs), hypertension, smoking, and male gender were identified as factors accelerating cerebral degenerative changes.

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These factors also accelerated mild cognitive decline and dementia.

Conclusions:

Intervention strategies targeting modifiable risk factors, alongside cholinesterase inhibitors, may prevent atropho-degenerative changes.
Preventative measures can help maintain optimal cognitive performance.