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Whole-brain diffusion MR histograms differ between MS subtypes.

A O Nusbaum1, C Y Tang, T Wei

  • 1Departments of Radiology, Mount Sinai School of Medicine, New York, NY, USA.

Neurology
|April 6, 2000
PubMed
Summary
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Quantitative whole-brain MR diffusion histograms reveal elevated average apparent diffusion coefficient (ADCave) in multiple sclerosis (MS) patients. This technique may help quantify MS lesion load and differentiate clinical subgroups.

Area of Science:

  • Neuroimaging
  • Quantitative MRI
  • Diffusion Tensor Imaging

Background:

  • Multiple Sclerosis (MS) exhibits macroscopic cerebral lesions on MRI, yet lesion burden poorly correlates with clinical disability.
  • Subtle white matter abnormalities in MS patients may exist even without visible lesions on conventional MRI.

Purpose of the Study:

  • To investigate differences in quantitative whole-brain magnetic resonance (MR) diffusion histograms between MS patients and healthy controls.
  • To assess the utility of diffusion histograms in characterizing MS-related white matter changes.

Main Methods:

  • Diffusion-weighted echoplanar MRI was performed on 25 subjects (13 MS, 12 controls).
  • Whole-brain average apparent diffusion coefficient (ADCave) histograms were computed pixel-by-pixel.

Related Experiment Videos

  • Statistical comparisons were made between MS patients and controls, and between MS subgroups.

    • Main Results:

    • MS patients showed elevated mean whole-brain ADCave with histograms shifted to higher values compared to controls.
    • Secondary progressive MS patients had higher ADCave values than relapsing-remitting MS patients.
    • Relapsing-remitting MS patients' histograms did not significantly differ from controls.

    Conclusions:

    • Whole-brain MR diffusion histograms can quantitatively assess overall cerebral lesion load in MS.
    • This imaging technique may differentiate between clinical subgroups within MS.