Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perspectives on spreading depression.

H Martins-Ferreira1, M Nedergaard, C Nicholson

  • 1Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Bloco G, Universidade Federal do Rio de Janeiro, Brazil.

Brain Research. Brain Research Reviews
|April 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An in vivo model of postinflammatory hyperpigmentation and erythema: clinical, colorimetric and molecular characteristics.

The British journal of dermatology·2021
Same author

The stability of care preferences following acute illness: a mixed methods prospective cohort study of frail older people.

BMC geriatrics·2020
Same author

Low and high body mass index in hidradenitis suppurativa patients-different subtypes?

Journal of the European Academy of Dermatology and Venereology : JEADV·2017
Same author

Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.

Cell death and differentiation·2015
Same author

External Dentin Stimulation Induces ATP Release in Human Teeth.

Journal of dental research·2015
Same author

Intervet symposium: bovine neosporosis.

Veterinary parasitology·2014
Same journal

Critical role of actin in modulating BBB permeability.

Brain research. Brain research reviews·2005
Same journal

Dual role of nitric oxide in adult neurogenesis.

Brain research. Brain research reviews·2005
Same journal

Dopamine-glutamate reciprocal modulation of release and motor responses in the rat caudate-putamen and nucleus accumbens of "intact" animals.

Brain research. Brain research reviews·2005
Same journal

CNS injury research; reviewing the last decade: methodological errors and a proposal for a new strategy.

Brain research. Brain research reviews·2005
Same journal

Contribution from neurophysiological and psychological methods to the study of motor imagery.

Brain research. Brain research reviews·2005
Same journal

Ceruloplasmin in neurodegenerative diseases.

Brain research. Brain research reviews·2005
See all related articles

Spreading depression (SD) is a neuronal event involving transient activity suppression. Research reveals its spread in the retina, astrocyte involvement via calcium waves, and significant extracellular ion shifts.

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Physiology

Background:

  • Spreading depression (SD) is a wave of neuronal silence spreading across brain tissue.
  • Understanding SD mechanisms is crucial for neurological research.

Purpose of the Study:

  • To review 30 years of research on Spreading Depression (SD).
  • To elucidate the roles of retinal intrinsic optical signals, astrocytes, and extracellular space in SD propagation.

Main Methods:

  • Analysis of intrinsic optical signals in isolated retinas during SD.
  • Investigation of astrocyte calcium (Ca2+) waves and gap junction involvement.
  • Electrode-based measurements of extracellular ion concentrations (K+, Na+, Cl-, Ca2+) and pH during SD.

Main Results:

Related Experiment Videos

  • SD in the retina exhibits circular propagation with distinct electrochemical equilibria.
  • Astrocytes mediate Ca2+ waves essential for SD initiation, but not sustained propagation.
  • SD causes significant extracellular ion shifts, including K+ increase and Na+, Cl-, Ca2+ decrease, alongside water efflux.

Conclusions:

  • SD involves complex interactions between neuronal activity, astrocytes, and extracellular milieu.
  • Astrocytic Ca2+ waves are important for SD initiation, while ion fluxes are critical for propagation.
  • Further research is needed to fully understand the interlocking cascade of events in Spreading Depression.