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Inflammation in horses.

R J MacKay1

  • 1Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, USA. mackayr@mail.vetmed.ufl.edu

The Veterinary Clinics of North America. Equine Practice
|April 7, 2000
PubMed
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Inflammation begins with antigen detection, concentrating immune cells and plasma at the site. The body then activates regulatory systems for repair, potentially leading to systemic responses like SIRS or immunosuppression.

Area of Science:

  • Immunology
  • Pathology
  • Cell Biology

Background:

  • Inflammation is a critical immune response initiated by antigen detection.
  • This process involves the concentration of plasma components and leukocytes at the affected site.

Purpose of the Study:

  • To describe the sequential events following the initiation of inflammation.
  • To elucidate the mechanisms of antigen elimination and the subsequent regulatory processes.
  • To outline the spectrum of systemic responses to localized inflammation.

Main Methods:

  • Review of inflammatory processes.
  • Analysis of cellular and chemical effector functions.
  • Examination of endogenous counter-regulatory systems.
  • Description of systemic acute phase responses.

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Main Results:

  • Inflammation concentrates immune effectors to destroy antigens.
  • Counter-regulatory systems initiate repair processes.
  • Inflammatory foci can trigger systemic inflammatory response syndrome (SIRS) or immunosuppression.

Conclusions:

  • Inflammation is a multi-stage process involving antigen elimination, repair initiation, and potential systemic effects.
  • Understanding these stages is crucial for managing inflammatory conditions and their sequelae.