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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Viral Hepatitis
1Department of Clinical Studies - New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA, USA.
Summary
Two equine hepatitis viruses, equine parvovirus-hepatitis and equine hepacivirus, cause liver disease in horses. Diagnosis involves PCR testing, and treatment focuses on supportive care for liver failure.
Area of Science:
- Veterinary Virology
- Equine Infectious Diseases
- Hepatology
Background:
- Two novel viral causes of equine hepatitis have emerged since 2012.
- Equine parvovirus-hepatitis is linked to acute hepatic necrosis (Theiler's disease).
- Equine hepacivirus is associated with chronic fibrosing hepatitis.
Purpose of the Study:
- To summarize current knowledge on equine hepatitis viruses.
- To highlight diagnostic and treatment challenges.
- To underscore the need for further research into transmission and risk factors.
Main Methods:
- Diagnosis involves excluding other hepatitis causes.
- Infection confirmation via serum or liver polymerase chain reaction (PCR).
Main Results:
- Equine parvovirus-hepatitis causes acute liver damage.
- Equine hepacivirus leads to chronic liver fibrosis.
- No specific antiviral treatments are currently available.
Conclusions:
- Effective diagnosis relies on PCR and differential diagnosis.
- Treatment is primarily supportive, managing liver failure and encephalopathy.
- Further research is crucial for understanding transmission and risk factors.
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