Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Optic disc blood flow measured by scanning laser-Doppler flowmetry using a new analysis program].

N Hayashi1, G Tomita, Y Kitazawa

  • 1Department of Ophthalmology, Self Defense Forces Central Hospital, Tokyo, Japan.

Nippon Ganka Gakkai Zasshi
|April 7, 2000
PubMed
Summary

Reduced optic disc rim blood flow correlates with advanced glaucoma changes in normal tension glaucoma (NTG) patients. This study used scanning laser-Doppler flowmetry (SLDF) to analyze ocular blood flow and disc morphology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adverse periocular reactions to five types of prostaglandin analogs.

Eye (London, England)·2012
Same author

Evaluation of the effect of aging on the retinal nerve fiber layer thickness using scanning laser polarimetry.

Journal of glaucoma·2009
Same author

Atypical retardation pattern in measurements of scanning laser polarimetry and its relating factors.

Eye (London, England)·2008
Same author

Performance of GDx VCC in eyes with peripapillary atrophy: comparison of three circle sizes.

Eye (London, England)·2006
Same author

Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography.

The British journal of ophthalmology·2005
Same author

Topical application of autologous serum for the treatment of late-onset aqueous oozing or point-leak through filtering bleb.

Eye (London, England)·2004

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Ocular Blood Flow Analysis

Context:

  • Normal tension glaucoma (NTG) is a progressive optic neuropathy.
  • Assessing the relationship between optic disc perfusion and structural damage is crucial for understanding NTG progression.
  • Current methods for analyzing ocular blood flow require refinement to accurately assess microcirculation at the optic disc.

Purpose:

  • To investigate the relationship between optic disc rim blood flow and optic disc morphology in normal tension glaucoma (NTG) patients.
  • To evaluate the utility of a new analysis program for scanning laser-Doppler flowmetry (SLDF) in quantifying perfusion at the optic disc.
  • To determine if blood flow differences correlate with visual field or disc structural differences in NTG.

Summary:

Related Experiment Videos

  • A novel analysis tool for Heidelberg retina flowmeter (HRF) scanning laser-Doppler flowmetry (SLDF) was used to measure mean blood flow at the optic disc rim in 42 eyes of 21 NTG patients.
  • Statistically significant correlations were found between mean optic disc rim blood flow and various optic disc morphological parameters, including Disk Area, Cup Area, Height Variation Contour, Cup Volume, Rim Volume, and Mean RNFL Thickness.
  • No statistically significant correlations were observed between mean optic disc rim blood flow and visual field parameters (mean deviation, corrected pattern standard deviation).

    • Impact:

    • The findings suggest that reduced blood flow in the optic disc rim is associated with more severe glaucomatous morphological changes in NTG.
    • This research highlights the potential of SLDF, analyzed with advanced software, as a tool for assessing disease severity and progression in NTG.
    • Understanding the link between perfusion and morphology can inform future diagnostic and therapeutic strategies for NTG.