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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Aspects of cardiovascular burden in pre-dialysis patients

T B Drüeke1

  • 1Département de Néphrologie, Hôpital Necker, Paris, France. drueke@necker.fr

Nephron
|April 8, 2000
PubMed

Insights

Cardiovascular disease (CVD) is a significant risk in chronic renal failure (CRF) patients. Addressing correctable factors like anemia, malnutrition, and inflammation in pre-dialysis patients may reduce CVD incidence and improve outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality in patients with chronic renal failure (CRF).
  • Dialysis patients exhibit a high prevalence of CVD risk factors, but the extent in pre-dialysis patients is less understood.
  • This review examines cardiovascular risk factors in pre-dialysis CRF patients.

Purpose of the Study:

  • To review the prevalence and impact of cardiovascular risk factors in patients with chronic renal failure prior to dialysis initiation.
  • To identify potentially correctable risk factors contributing to cardiovascular disease in this population.

Main Methods:

  • A review of published data was conducted.
  • The focus was on examining the role of potentially correctable cardiovascular risk factors in pre-dialysis patients.

Main Results:

  • Anemia is a significant cardiovascular risk factor in CRF patients, and its partial correction with recombinant human erythropoietin can improve cardiac dysfunction, including left ventricular hypertrophy.
  • Malnutrition and inflammation are identified as recently recognized, potentially correctable cardiovascular risk factors in pre-dialysis CRF patients.

Conclusions:

  • Patients initiate dialysis with a substantial cardiovascular burden, often including prior myocardial infarction or stroke.
  • Factors such as malnutrition and inflammation contribute to the elevated incidence of cardiovascular events.
  • Early treatment of anemia, prevalent in pre-dialysis patients, may decrease CVD incidence and enhance long-term outcomes.
Abstract

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