[Experimental carbon disulfide-induced encephalopathy]

The histopathological and ultrastructural aspects of cerebral cortex were followed up in the white rat injected intraperitoneally with carbon disulphide at 5 mg/kg body weight/week, in a chronic experiment--3, 6, 10 months. Important neuronal damages like: neuronal dystrophy's to neurolysis affecting the pyramidal and granular cells, neuronophagy, nodular and diffuse glial reaction, in the absence of atherosclerotic lesions were noticed. The lesions developed after 3 months and become more extended at 6 months and 10 months: it persists even after 2 months from the moment when the administration ceased.