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Related Experiment Videos

[Experimental carbon disulfide-induced encephalopathy].

C Mihalache1, G Mihalache, L I Mihalache

  • 1Disciplina de Medicină Muncii, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|July 1, 1997
PubMed
Summary

Chronic carbon disulfide exposure in rats caused significant neuronal damage in the cerebral cortex, including cell death and glial reactions, persisting even after exposure ceased.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Histopathology

Context:

  • Investigating the long-term effects of carbon disulfide (CS2) exposure on the central nervous system.
  • Utilizing a rodent model (white rat) for chronic toxicity studies.

Purpose:

  • To elucidate the histopathological and ultrastructural changes in the cerebral cortex following chronic intraperitoneal administration of carbon disulfide.
  • To assess the progression and persistence of neuronal damage induced by CS2.

Summary:

  • White rats received weekly intraperitoneal injections of carbon disulfide (5 mg/kg) for 3, 6, and 10 months.
  • Significant neuronal damages were observed, including neuronal dystrophy, neurolysis of pyramidal and granular cells, neuronophagy, and glial reactions.
  • These lesions developed by 3 months, worsened at 6 and 10 months, and persisted for at least 2 months after CS2 administration stopped, notably without atherosclerotic changes.

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Impact:

  • Provides critical insights into the neurotoxic effects of carbon disulfide, particularly on the cerebral cortex.
  • Highlights the potential for persistent neurological damage even after cessation of exposure.
  • Informs risk assessment and potential therapeutic strategies for individuals exposed to carbon disulfide in occupational or environmental settings.