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Related Experiment Videos

Understanding the overdispersed molecular clock.

D J Cutler1

  • 1Center for Population Biology, University of California, Davis, California 95616, USA. djc14@cwru.edu

Genetics
|April 11, 2000
PubMed
Summary
This summary is machine-generated.

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The molecular clock is often irregular, deviating from neutral evolution predictions. Deleterious mutations or slow population parameter changes likely explain this overdispersed molecular clock, impacting protein evolution rates.

Area of Science:

  • Evolutionary Biology
  • Molecular Evolution
  • Population Genetics

Background:

  • Protein evolution rates can be irregular, deviating from neutral models.
  • This pattern is termed the "overdispersed molecular clock" (R(T) > 1).

Purpose of the Study:

  • To analyze factors contributing to the overdispersed molecular clock.
  • To model protein substitution rates under various evolutionary scenarios.

Main Methods:

  • Developed a general stationary model for molecular evolution assuming infinite sites and no recombination.
  • Analyzed existing and new models for the overdispersed molecular clock.

Main Results:

  • The index of dispersion R(T) is influenced by slow fluctuations, advantageous/deleterious mutations, and mutation interactions.

Related Experiment Videos

  • Deleterious mutations increase R(T); advantageous mutations decrease R(T).
  • A model incorporating deleterious mutations sufficiently explains observed R(T) values.

    • Conclusions:

    • Observed R(T) values suggest most mutations are deleterious or population parameters change slowly.
    • This model can help differentiate selective sweeps from background selection.