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Low extracellular Mg2+ concentrations suppress phagocytosis in vitro by alveolar macrophages from rats
S Ishiguro1, A Miyamoto, T Tokushima
1Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, Japan.
Magnesium Research
|April 13, 2000
Abstract:
The aim of this study was to assess the effects of extracellular Mg2+ concentrations on phagocytosis in vitro by alveolar macrophages from rats. Phagocytosis was suppressed in the presence of low, but not high, Mg2+ concentrations. Vanadate, a Mg(2+)-ATPase inhibitor, suppressed phagocytosis. In the presence of a low Mg2+ concentration or vanadate, the cytosolic free Ca2+ concentration ([Ca2+]i) increased, but the cytosolic free Mg2+ concentration did not. These results suggest that low extracellular Mg2+ concentrations and vanadate suppress phagocytosis by rat alveolar macrophages by increasing [Ca2+]i.