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Related Experiment Videos

[Drug-induced gynecomastia].

F C Hugues1, C Gourlot, C Le Jeunne

  • 1Service de Médecine Interne II, Hôpital Laennec, Faculté de Médecine Necker-Enfants Malades, Paris.

Annales De Medecine Interne
|April 13, 2000
PubMed
Summary

Drug-induced gynecomastia is common, often caused by hormonal imbalances or elevated prolactin. Various medications, including antiandrogens and chemotherapy, can lead to this condition.

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Area of Science:

  • Endocrinology
  • Pharmacology

Context:

  • Gynecomastia, the enlargement of male breast tissue, can be a side effect of numerous medications.
  • Understanding drug-induced gynecomastia is crucial for accurate diagnosis and patient management.

Purpose:

  • To review common and less common medications implicated in causing gynecomastia.
  • To discuss the mechanisms behind drug-induced gynecomastia, focusing on hormonal imbalances.

Summary:

  • Drugs frequently cause gynecomastia by altering the serum estrogen/androgen ratio or increasing prolactin levels.
  • Common culprits include sex hormones, antiandrogens, spironolactone, cimetidine, verapamil, and alkylating agents.
  • Other potential agents include diazepam, antidepressants, neuroleptics, calcium channel blockers, captopril, and omeprazole.

Impact:

  • Highlights the importance of considering medication history in patients presenting with gynecomastia.
  • Provides a comprehensive overview of drugs associated with gynecomastia for healthcare professionals.
  • Discusses diagnostic criteria for establishing drug causality in gynecomastia cases.

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