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Related Experiment Videos

Orienting axon growth: spinal nerve segmentation and surround-repulsion.

D Tannahill1, J M Britto, M M Vermeren

  • 1Department of Anatomy, University of Cambridge, United Kingdom. dt10003@mole.bio.cam.ac.uk

The International Journal of Developmental Biology
|April 13, 2000
PubMed
Summary

Spinal axon pathfinding in vertebrate embryos relies on both contact and chemical repulsion. Surround-repulsion mechanisms guide motor and sensory axons through somites, crucial for neural development.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Embryology

Background:

  • Spinal nerve development involves complex axon pathfinding.
  • Somites exhibit antero-posterior polarity influencing neural growth.

Purpose of the Study:

  • To investigate the guidance mechanisms determining spinal axon trajectories in vertebrate embryos.
  • To elucidate the roles of contact repulsion and chemorepulsion in somite navigation.

Main Methods:

  • Analysis of spinal nerve trajectories in higher vertebrate embryos.
  • Review of molecular candidates for contact repellents.
  • Investigation of diffusible repellents from embryonic structures.

Main Results:

  • Axon orientation is governed by simultaneous contact repulsion and chemorepulsion.

Related Experiment Videos

  • Motor and sensory axons are repelled from the posterior half of somites.
  • Diffusible repellents from the notochord and dermamyotome guide sensory axon trajectories dorsally.

    • Conclusions:

    • Repulsion by surrounding tissues ('surround-repulsion') is a primary force in 3D axon growth.
    • Distinct repulsive cues dictate both antero-posterior and dorsoventral navigation.
    • Understanding these mechanisms is key to comprehending neural development.