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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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A novel transcription factor, T-bet, directs Th1 lineage commitment

S J Szabo1, S T Kim, G L Costa

  • 1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Cell
|April 13, 2000
PubMed
Summary

T-bet, a Th1-specific transcription factor, drives T helper cell differentiation. It activates the IFNgamma gene and represses Th2 cytokines, initiating Th1 lineage development.

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