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The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity
E L Fritzen1, A S Brightwell, L A Erickson
1Medicinal Chemistry Research, Pharmacia & Upjohn Company, Kalamazoo, MI, 49001, USA. edward.1.fritzen@am.pnu.com
Bioorganic & Medicinal Chemistry Letters
|April 13, 2000
Abstract:
A solid phase synthesis of substituted tetrahydroisoquinolines was developed and used to prepare directed libraries of compounds for screening against the protein phosphatase, CDC25B. From these libraries, a compound was found having approximately a 4-fold improvement in activity.