Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor suppressor p53: regulation and function.

K Somasundaram1

  • 1Laboratory of Molecular Oncology and Cell Cycle Regulation University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|April 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fault-tolerance amplification in line graphs: a framework for resilient PMU placement in power networks.

Scientific reports·2026
Same author

Deep learning for text summarization using NLP for automated news digest.

Scientific reports·2025
Same author

Revolutionizing healthcare: A review on cutting-edge innovations in Raspberry Pi-powered health monitoring sensors.

Computers in biology and medicine·2025
Same author

Graph convolution network for fraud detection in bitcoin transactions.

Scientific reports·2025
Same author

An effective COVID-19 classification in X-ray images using a new deep learning framework.

Journal of X-ray science and technology·2025
Same author

THOR-05F biofidelity evaluation in reclined and upright seated postures subjected to frontal crash pulses.

Accident; analysis and prevention·2023

The p53 protein is crucial for preventing cancer by maintaining genomic stability. Understanding its function and mutations is key for developing effective cancer therapies and gene replacement strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The p53 protein acts as a critical transcription factor, safeguarding genomic integrity by regulating cell cycle progression and survival.
  • Mutations in the p53 gene are prevalent in human cancers, often rendering tumors resistant to conventional treatments like chemotherapy and radiotherapy.
  • The efficacy of cancer therapies relies partly on p53's ability to induce programmed cell death following DNA damage.

Purpose of the Study:

  • To review the current understanding of p53 protein structure, activation mechanisms, and effector functions.
  • To highlight the significance of p53 in cancer development and treatment response.
  • To explore gene replacement therapy as a potential strategy for p53-mutated cancers.

Main Methods:

Related Experiment Videos

  • This review synthesizes existing scientific literature on p53.
  • It focuses on recent discoveries regarding p53 activation pathways, including post-translational modifications.
  • The identification of novel p53 target genes is also discussed.

    • Main Results:

    • p53 mutations are a frequent hallmark of cancer, correlating with poor prognosis and treatment resistance.
    • Recent research has elucidated various pathways controlling p53 activation, particularly post-translational modifications.
    • New target genes regulated by p53 have been identified, expanding our knowledge of its functional network.

    Conclusions:

    • Restoring functional p53 through gene replacement therapy presents a promising avenue for treating cancers with p53 mutations.
    • A comprehensive understanding of p53's structure, activation, and targets is essential for advancing cancer treatment strategies.
    • Further research into p53 pathways and its role in cancer is critical for improving patient outcomes.