Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A role for MHC class II antigen processing in B cell development.

T W Sproul1, P C Cheng, M L Dykstra

  • 1Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.

International Reviews of Immunology
|April 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population.

Journal of psychiatric research·2024
Same author

The Digestive Diverticula in the Carnivorous Nudibranch, <i>Melibe leonina</i>, Do Not Contain Photosynthetic Symbionts.

Integrative organismal biology (Oxford, England)·2021
Same author

Activation of the NLRP3 and AIM2 inflammasomes in a mouse model of <i>Schistosoma mansoni</i> infection.

Journal of helminthology·2019
Same author

On the Giant Octopus (Octopus giganteus) and the Bermuda Blob: Homage to A. E. Verrill.

The Biological bulletin·2017
Same author

Annual Viral Expression in a Sea Slug Population: Life Cycle Control and Symbiotic Chloroplast Maintenance.

The Biological bulletin·2017
Same author

Prevalence and genotype of Giardia duodenalis from faecal samples of stray dogs in Hualien city of eastern Taiwan.

Tropical biomedicine·2014
Same journal

Leptin in metabolic-immune crosstalk: Mechanisms of T cell regulation and implications for autoimmune disease therapy.

International reviews of immunology·2026
Same journal

Metabolic alterations in the tumor microenvironment influence the anti-tumor immune function of CD8<sup>+</sup> T cells via epigenetic modifications.

International reviews of immunology·2026
Same journal

Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection.

International reviews of immunology·2026
Same journal

Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota.

International reviews of immunology·2026
Same journal

Upregulation of ADAM10 reinforces CD8<sup>+</sup> T cells toward exhaustion in the TME.

International reviews of immunology·2026
Same journal

PTX3 promotes macrophage efferocytosis and inflammation resolution in granulomatous mastitis.

International reviews of immunology·2026
See all related articles

Mature B cells require antigen processing and presentation to helper T cells for antibody production. Immature B cells undergo negative selection, but their antigen presentation role is less understood.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mature B cells differentiate into antibody-secreting or memory cells upon antigen encounter.
  • This response depends on B cell antigen receptor (BCR) signaling and antigen presentation to T cells.
  • Immature B cells undergo negative selection (apoptosis, anergy, or receptor editing) after BCR signaling.

Purpose of the Study:

  • To review the role of antigen processing and presentation by mature B cells.
  • To explore the less understood role of antigen processing and class II expression in immature B cell development.
  • To understand how these processes influence B cell fate decisions.

Main Methods:

  • Review of current scientific literature on B cell antigen processing and presentation.
  • Analysis of evidence regarding BCR signaling and its downstream effects.

Related Experiment Videos

  • Examination of the role of MHC class II expression in B cell development.

    • Main Results:

    • Antigen processing and presentation to helper T cells are critical for mature B cell responses.
    • Antigen presentation via BCR is acquired late in B cell development.
    • MHC class II expression is early and crucial for generating long-lived mature B cells.

    Conclusions:

    • Antigen processing and presentation are key determinants of mature B cell fate.
    • Immature B cells may not present BCR-bound antigen during negative selection.
    • Early MHC class II expression is vital for generating functional mature B cells.