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Sleep deprivation per se does not decrease the hypercapnic ventilatory response in humans.

C M Spengler1, S A Shea

  • 1Circadian, Neuroendocrine, and Sleep Disorders Section, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. spengler@physiol.unizh.ch

American Journal of Respiratory and Critical Care Medicine
|April 14, 2000
PubMed
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Sleep deprivation does not affect respiratory control. This study found no significant changes in hypercapnic ventilatory response (HCVR) or resting ventilation after 24 hours of sleep loss under controlled conditions.

Area of Science:

  • Physiology
  • Sleep Science
  • Respiratory Control

Background:

  • Previous studies suggest sleep deprivation reduces hypercapnic ventilatory response (HCVR).
  • Potential confounding factors like uncontrolled activities and environmental influences may have affected prior findings.
  • The direct impact of sleep deprivation on respiratory regulation requires clarification.

Purpose of the Study:

  • To isolate and determine the "pure" effect of sleep deprivation on respiratory control.
  • To investigate the influence of sleep loss on central chemoreceptor sensitivity.
  • To assess changes in resting ventilation, oxygen consumption (V O2), and carbon dioxide production (V CO2) during sleep deprivation.

Main Methods:

  • 10 subjects underwent 41 hours of continuous wakefulness in a controlled laboratory environment.

Related Experiment Videos

  • Strict control of posture, meals, social interaction, light (10 lux), and temperature was maintained.
  • Hypercapnic ventilatory response (HCVR), resting ventilation, V O2, and V CO2 were measured every 2 hours using polysomnography and capnography.

    • Main Results:

    • No significant changes were observed in resting ventilation, V O2, or V CO2 after 24 hours of sleep deprivation.
    • Mean HCVR showed a non-significant 17% increase (3.12 to 3.54 L x min(-1) x mm Hg(-1)) after 24 hours of sleep deprivation.
    • Respiratory variables remained stable throughout the 41-hour controlled wakefulness period.

    Conclusions:

    • Sleep deprivation per se does not reduce central chemoreceptor sensitivity.
    • Resting ventilation and metabolism are not significantly altered by acute sleep deprivation under controlled conditions.
    • Previous findings of reduced HCVR after sleep loss may be attributable to uncontrolled variables in experimental settings.