Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Concurrent Paclitaxel and Radiation Therapy for Solid Tumors.

Choy1, Akerley, Glantz

  • 1Center for Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Cancer Control : Journal of the Moffitt Cancer Center
|July 1, 1996
PubMed
Summary

Paclitaxel combined with radiation therapy shows feasibility and tolerability in treating various cancers, including lung, brain, and gastrointestinal tumors. Early results indicate observed antitumor responses, warranting further investigation into this combination cancer treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lessons learned from genetic and nutritional iron deficiencies.

Nutrition reviews·2004
Same author

Correlation of endoscopic and histologic findings before and after treatment for nasopharyngeal carcinoma

Head & neck·2001
Same author

A Study on the Adsorption Characteristics of Orthophosphates on Rutile-Type Titanium Dioxide in Aqueous Solutions.

Journal of colloid and interface science·2000
Same author

Phase behavior and material properties of hollow nanoparticles

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2000
Same author

Nonlocal electron kinetics in a planar inductive helium discharge

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2000
Same author

Anaerobic Infections of the Lung.

Current infectious disease reports·2000

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Oncology

Background:

  • Combination therapy using radiation and chemotherapy is a promising strategy for enhanced cancer treatment.
  • Preclinical data suggest potential additive or synergistic effects between paclitaxel and radiation.

Purpose of the Study:

  • To evaluate the safety and tolerability of combined paclitaxel and radiation therapy.
  • To explore the initial effectiveness of this combination in specific cancer types.

Main Methods:

  • Conducted a series of Phase I and II clinical trials.
  • Included patients with non-small cell lung cancer, high-grade astrocytic brain tumors, and pancreatic and gastric cancers.
  • Assessed tolerance, toxicity, and antitumor responses.

Related Experiment Videos

Main Results:

  • The combined treatment was generally well-tolerated across patient groups.
  • Esophagitis was identified as a dose-limiting toxicity for intrathoracic tumors.
  • Common toxicities included peripheral neuritis and cutaneous reactions, with mild hematologic toxicity.

Conclusions:

  • Paclitaxel in combination with concurrent radiation therapy is feasible at the tested doses and schedules.
  • The combination demonstrated observable antitumor responses in the studied patient populations.
  • Further research is supported by these findings for advanced cancer treatment strategies.