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Updated: Aug 1, 2026

Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)
Published on: September 13, 2018
Detection of upper airway resistance syndrome using a nasal cannula/pressure transducer
M D Epstein1, S A Chicoine, R C Hanumara
1Department of Medicine and Sleep Disorders Center, Roger Williams Medical Center, Providence, RI, USA.
Study Objectives:
To determine the diagnostic utility of a nasal cannula/pressure transducer (NC), in comparison to thermistor (TH), during routine, clinical nocturnal polysomnography (NPSG).
Design:
We analyzed the respiratory arousal index (RAI) using TH (RAI-TH) or NC (RAI-NC) in patients with suspected sleep-disordered breathing (SDB).
Setting:
Sleep disorders center of a university-affiliated teaching hospital.
Patients:
Fifty consecutive, nonselected patients referred for evaluation of suspected SDB.
Measurements And Results:
Twenty patients were found to have obstructive sleep apnea/hypopnea syndrome (OSA), 25 had upper airway resistance syndrome (UARS), and 5 had primary snoring (PS). Mean RAI-NC was greater than the mean RAI-TH by 25%, 302%, and 500% in OSA, UARS, and PS, respectively. RAI-NC was >/= 14 (mean, 25.2) in UARS and < 14 (mean, 9) in PS. Mean RAI-TH was 8.4 in UARS and 1.8 in PS, with significant overlap between the two groups.
Conclusions:
NC is more sensitive than TH in detecting respiratory events during NPSG and may represent a simple, objective means to identify UARS among patients with a range of SDB.
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