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Sex differences in left ventricular geometry in aortic stenosis: impact on outcome
D L Milavetz1, S N Hayes, S A Weston
1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Chest
|April 18, 2000
Summary
Sex differences in left ventricular (LV) geometry exist in patients with aortic stenosis, but these distinctions disappear when normalized for body surface area. Surgical outcomes were similar between men and women.
Area of Science:
- Cardiology
- Cardiac Surgery
- Medical Imaging
Background:
- Surgical aortic stenosis requires understanding patient-specific factors.
- Left ventricular (LV) geometry and outcomes may differ between sexes.
Purpose of the Study:
- To investigate sex-based differences in left ventricular (LV) geometry and surgical outcomes in patients with aortic stenosis.
Main Methods:
- Echocardiography was performed on 92 women and 82 men prior to aortic valve replacement.
- Analysis focused on LV cavity size, ejection fraction, and LV mass.
- Outcomes included surgical mortality and 5-year survival rates.
Main Results:
- Women exhibited smaller LV cavity size and higher ejection fraction compared to men.
- LV mass was greater in men, but this difference was not significant after body surface area correction.
- The prevalence of LV hypertrophy and 5-year survival rates were similar between sexes.
Conclusions:
- While some LV geometry parameters differ between sexes in aortic stenosis, these are often normalized by body surface area.
- No significant differences in surgical mortality or long-term outcomes were observed between men and women.