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HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks
A Papa1, E Papadimitriou, G Adwan
1National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
FEMS Immunology and Medical Microbiology
|April 18, 2000
Abstract:
The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.