Related Experiment Video
Updated: Jul 20, 2026

Cecal Ligation Puncture Procedure
Published on: May 7, 2011
Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations
1Department of Internal Medicine, Rush Medical College, Chicago, Illinois, USA. rbalk@rush.edu
Abstract:
Severe sepsis and septic shock are frequently encountered conditions in today's hospital environment. The incidence appears to be increasing despite our growing armamentarium of antibiotics and our enhanced knowledge of the pathophysiologic processes at play. The clinical presentation may take a variety of forms, especially in patients at the extremes of age and in the immunocompromised population. A high index of suspicion and prompt institution of appropriate antimicrobial treatment is mandatory for a successful outcome. It is hoped that adoption of uniform definitions will aid in research and in effective communication concerning sepsis and its adverse sequelae.
Related Concept Videos
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Pulmonary Embolism I: Introduction
Acute Pyelonephritis I: Introduction
Acute Kidney Injury III: Clinical Manifestations
Bacterial Meningitis I: Introduction
Pulmonary Embolism I: Introduction

