Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polydimethylsiloxane/polyether-mixed macrodiol-based polyurethane elastomers: biostability.

D J Martin1, L A Warren, P A Gunatillake

  • 1The Cooperative Research Centre For Cardiac Technology, University of New South Wales, Graduate School of Biomedical Engineering, Sydney, Australia.

Biomaterials
|April 18, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spectroscopic and theoretical investigation of the [Fe<sub>2</sub>(bdt)(CO)<sub>6</sub>] hydrogenase mimic and some catalyst intermediates.

Physical chemistry chemical physics : PCCP·2019
Same author

Effect of pain neurophysiology education on physiotherapy students' understanding of chronic pain, clinical recommendations and attitudes towards people with chronic pain: a randomised controlled trial.

Physiotherapy·2017
Same author

The intra- and inter-observer reliability of a novel protocol for two-point discrimination in individuals with chronic low back pain.

Physiological measurement·2016
Same author

Quantitative T1ρ mapping links the cerebellum and lithium use in bipolar disorder.

Molecular psychiatry·2015
Same author

Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping.

Molecular psychiatry·2015
Same author

Authors' reply to comment by Grant et al.

European journal of pain (London, England)·2014
Same journal

Cationic nanotrap curbs UVB-induced cutaneous photodamage via exosomal cfNA capture.

Biomaterials·2026
Same journal

A protein-initiated polymerization cascade enables a self-eliminating powder tissue adhesive for diabetic ulcer repair.

Biomaterials·2026
Same journal

Oral colon-targeted micro-nano formulation engineered in microfluid for synergistic therapy of inflammatory bowel disease.

Biomaterials·2026
Same journal

Manganese@Gold cluster-coordinated covalent organic frameworks-based artificial metalloenzymes with cascade biocatalysis and amplified systemic stimulation to combat malignant tumor metastasis.

Biomaterials·2026
Same journal

Remodeling TME via feedback-driven photothermal-ferroptosis-immune cascade.

Biomaterials·2026
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
See all related articles

New thermoplastic polyurethanes (TPUs) using mixed poly(hexamethylene oxide) (PHMO) and poly(dimethylsiloxane) (PDMS) macrodiols show excellent biostability. The 80% PDMS formulation offers a promising balance of flexibility, strength, and biocompatibility for medical applications.

Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Polymer Chemistry

Background:

  • Thermoplastic polyurethanes (TPUs) are widely used biomaterials.
  • Improving the biostability and mechanical properties of TPUs is crucial for advanced medical applications.
  • Tailoring TPU composition offers a route to optimize performance.

Purpose of the Study:

  • To synthesize and characterize novel TPUs by blending poly(hexamethylene oxide) (PHMO) and poly(dimethylsiloxane) (PDMS) macrodiols.
  • To evaluate the biostability and mechanical properties of these new TPU formulations.
  • To identify optimal TPU compositions for enhanced biocompatibility and performance.

Main Methods:

  • Synthesis of four TPU elastomers with varying ratios of PDMS and PHMO macrodiols (100:0, 80:20, 50:50, 20:80), maintaining a 60% macrodiol weight fraction.

Related Experiment Videos

  • Reaction of mixed macrodiols with 4,4'-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BDO).
  • Assessment of biostability via strained subcutaneous implantation in sheep for three months, followed by microscopic examination. Mechanical properties were also tested.

    • Main Results:

    • Successful synthesis of flexible, PDMS-rich TPUs with promising biostability.
    • The TPU formulation containing 80% PDMS macrodiol demonstrated the best combination of flexibility, strength, and biostability.
    • Control materials (Pellethane 2363-80A and 2363-55D) were used for comparison.

    Conclusions:

    • The mixed macrodiol approach is effective for producing soft, flexible polyurethanes with excellent biostability.
    • The 80% PDMS formulation represents a highly promising biomaterial candidate.
    • These novel TPUs hold potential for various biomedical applications requiring durable and biocompatible materials.