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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Gianotti-Crosti syndrome presenting as lichenoid dermatitis
C M Stefanato1, L J Goldberg, W K Andersen
1Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA.
The American Journal of Dermatopathology
|April 19, 2000
Summary
Gianotti-Crosti syndrome, a childhood rash, can present with a lichenoid dermatitis pattern. This case highlights the importance of considering this presentation in pediatric differential diagnoses.
Area of Science:
- Pediatric Dermatology
- Dermatopathology
Background:
- Gianotti-Crosti syndrome (papular acrodermatitis of childhood) is an uncommon, self-limited viral exanthem.
- Typical histopathology shows nonspecific findings like spongiosis and superficial perivascular infiltrate.
Observation:
- A case of Gianotti-Crosti syndrome in a 2.5-year-old boy presented with papules and plaques on the face and extremities, and cervical lymphadenopathy.
- Histopathologic analysis revealed a dense lichenoid lymphohistiocytic infiltrate with epidermal changes and CD1a+ Langerhans cells.
Findings:
- The observed histopathologic pattern, characterized by a lichenoid infiltrate, is not widely recognized in Gianotti-Crosti syndrome.
- This case demonstrates that Gianotti-Crosti syndrome can manifest as lichenoid dermatitis.
Implications:
- Pediatric lichenoid infiltrates should include Gianotti-Crosti syndrome in their differential diagnosis.
- Recognizing this variant presentation improves diagnostic accuracy for this childhood condition.
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