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[Sentinel node navigation surgery in breast cancer].

S Imoto1

  • 1Division of Breast Surgery National Cancer Center Hospital East, Kashiwa, Japan.

Nihon Geka Gakkai Zasshi
|April 25, 2000
PubMed
Summary

Sentinel node navigation surgery (SNNS) offers a reliable alternative to axillary lymph node dissection (ALND) for early breast cancer. This technique successfully identified sentinel lymph nodes in 97% of cases, allowing omission of ALND in 63%.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Context:

  • Sentinel node navigation surgery (SNNS) is an evolving technique to minimize axillary lymph node dissection (ALND) in breast cancer patients.
  • Standard surgical protocols for SNNS involve choices in tracer injection sites, radioactivity dosage, and timing, alongside diverse surgical approaches.
  • Previous studies indicate SNNS is both feasible and dependable for patients with sentinel node-negative early breast cancer.

Purpose:

  • To evaluate the feasibility and efficacy of sentinel node navigation surgery (SNNS) in early breast cancer treatment.
  • To assess the identification rate of sentinel lymph nodes and the rate of omission of axillary lymph node dissection (ALND).
  • To explore the potential of SNNS as a future standard surgical procedure for breast cancer.

Summary:

  • SNNS, utilizing indigocarmine and dual radiotracers (technetium-99m-human serum albumin and technetium-99m-tin colloid), achieved a 97% sentinel lymph node identification rate by January 2000.
  • In 90 examined cases, ALND was successfully omitted in 57 (63%) patients.
  • The study initiated SNNS in January 1998, following a feasibility assessment in 200 early breast cancer cases.

Impact:

  • SNNS demonstrates high efficacy in identifying sentinel lymph nodes, potentially reducing the need for extensive axillary lymph node dissection.
  • The findings suggest SNNS is a reliable procedure for early breast cancer, with a significant rate of ALND omission.
  • Further randomized trials are recommended to compare clinical outcomes, arm morbidity, and cost-effectiveness of SNNS versus ALND.

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