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Related Experiment Videos

Mesenteric vasoconstriction in response to hemorrhagic shock.

T Toung1, P M Reilly, K C Fuh

  • 1Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-4685, USA.

Shock (Augusta, Ga.)
|April 25, 2000
PubMed
Summary

Hemorrhagic shock causes selective mesenteric ischemia via disproportionate mesenteric vasospasm. The renin-angiotensin axis primarily mediates this response, similar to cardiogenic shock.

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Area of Science:

  • Cardiovascular Physiology
  • Gastrointestinal Physiology

Background:

  • Cardiogenic shock causes mesenteric ischemia via the renin-angiotensin axis.
  • Understanding neurohumoral mechanisms in hypovolemic shock is crucial.

Purpose of the Study:

  • Characterize systemic and mesenteric hemodynamic responses to hypovolemic shock.
  • Identify neurohumoral control mechanisms of mesenteric ischemia in hemorrhagic shock.

Main Methods:

  • Graded hemorrhage (12.5-50% blood volume) in swine.
  • Measured systemic and mesenteric pressures/flows; calculated resistances.
  • Repeated experiments after alpha-adrenergic, vasopressin, or renin-angiotensin blockade.

Main Results:

  • Hemorrhagic shock induced graded systemic hypotension and peripheral vasoconstriction.

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  • Disproportionate mesenteric vasoconstriction and ischemia occurred.
  • Mesenteric ischemia was blocked by renin-angiotensin axis blockade (enalapril), but not alpha-adrenergic or vasopressin blockade.

    • Conclusions:

    • Hemorrhagic shock, like cardiogenic shock, causes selective mesenteric ischemia.
    • Disproportionate mesenteric vasospasm is primarily mediated by the renin-angiotensin axis.