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Human papillomavirus type 16 E7 oncoprotein represses transcription of human fibronectin
1School of Dentistry, University of California at Los Angeles, Los Angeles, California 90095-1668, USA.
Journal of Virology
|April 25, 2000
Abstract:
The E7 oncoprotein encoded by human papillomavirus (HPV) type 16 repressed the transcription of fibronectin, a key component of the extracellular matrix. This repression, detected in several HPV-positive nontumorigenic and tumorigenic cell lines, was abolished when the Cys-X-X-Cys repeats in E7 were disrupted.