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Multidrug resistant Salmonella
1Department of Pathology, Sir Hurkisondas Nurrotumdas Hospital, Mumbai.
Indian Journal of Medical Sciences
|April 25, 2000
Summary
Salmonella typhi remains the most frequent cause of enteric fever in Mumbai. Alarmingly, multidrug resistance is increasing, with quinolone derivatives showing the most effectiveness against resistant strains.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Enteric fever, primarily caused by Salmonella species, poses a significant public health challenge.
- Understanding the circulating serotypes and their antimicrobial resistance patterns is crucial for effective treatment and control.
Purpose of the Study:
- To characterize Salmonella strains isolated from enteric fever cases in Mumbai.
- To assess the antibiotic susceptibility profiles and resistance transfer mechanisms of these strains.
Main Methods:
- Isolation and identification of Salmonella strains using standard biochemical and serological tests.
- Bacteriophage typing, antibiotic sensitivity testing, and conjugation experiments were performed.
- Analysis of 326 strains collected over a two-year period (May 1992-July 1994).
Main Results:
- Salmonella typhi was the predominant serotype (75.46%), followed by S. paratyphi A (9.5%), S. typhimurium (5.52%), and others.
- A high prevalence of multidrug resistance was observed, particularly against chloramphenicol, ampicillin, and cotrimoxazole.
- Conjugation experiments indicated direct and en bloc transfer of resistance patterns.
- Ciprofloxacin demonstrated the highest efficacy among tested drugs.
Conclusions:
- Salmonella typhi continues to be the leading cause of enteric fever in the region.
- There is a concerning rise in multidrug-resistant Salmonella strains, necessitating careful antibiotic selection.
- Quinolone derivatives represent a promising therapeutic option for multidrug-resistant enteric fever.