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IMGT/HLA database--a sequence database for the human major histocompatibility complex.

J Robinson1, A Malik, P Parham

  • 1Cancer & Immunogenetics Laboratory, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

Tissue Antigens
|April 25, 2000
PubMed
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The IMGT/HLA Database provides essential human major histocompatibility (MHC) sequences and analysis tools. It supports the World Health Organization

Area of Science:

  • Immunogenetics
  • Bioinformatics

Background:

  • The human major histocompatibility (MHC) system, known as Human Leukocyte Antigen (HLA) in humans, is crucial for immune response.
  • Accurate and accessible sequence data is vital for immunological research and clinical applications.

Purpose of the Study:

  • To describe the IMGT/HLA Database, a specialized resource for human MHC/HLA sequences.
  • To highlight the database's functionalities for sequence retrieval, analysis, and submission.

Main Methods:

  • Curating and maintaining a comprehensive collection of officially recognized HLA alleles.
  • Developing online tools for sequence analysis, including allele reports and alignment capabilities.
  • Implementing a submission tool for direct data contribution to the WHO Nomenclature Committee.

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Main Results:

  • The database contains 1,015 HLA alleles from over 2,270 sequences as of release 1.4.1 (November 1999).
  • The IMGT/HLA website experienced approximately 100,000 hits between December 1998 and December 1999.
  • The system is designed as a model for future MHC databases for other species.

Conclusions:

  • The IMGT/HLA Database serves as a critical, centralized resource for human HLA sequence information.
  • Its integrated tools facilitate research and data submission, supporting the standardization of HLA nomenclature.
  • The database's success and planned expansion underscore its importance in immunogenetics research.